![]() ![]() The importance of protonated chiral bases for enantioselection was also shown. Evidence for non-binding of chiral base to cobalt complexes was presented in the case of latter system, i.e., it was shown that the catalytic site and the enantioselectivity-determining site are separated in this system, as in enzymes. High degrees of enantioselectivities (≈78%) are achieved in the hydrogenation of α-diketones. These gave corresponding optically active reduction products, and in some cases, optically active reductive dimerization products. ![]() The catalytic asymmetric hydrogenations of α-diketones, α-keto carboxylates, α-(acylamino)acrylates, α-phenylacrylophenone, and α-phenylacrylate were examined with bis(dimethylglyoximato)cobalt(II)–chiral cocatalyst (amino alcohol) and with simple achiral base coordinated bis(dimethylglyoximato)cobalt(II)–chiral cocatalyst (amino alcohol) systems. ![]()
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